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| The important influence of synemin | |
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| Tweet Topic Started: Friday Jan 24 2014, 09:36 AM (96 Views) | |
| cusabiozdy | Friday Jan 24 2014, 09:36 AM Post #1 |
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Synemin(SYNM) is an intermediate filament(IF). Synemin function is to integrate mechanical stress and maintain structural integrity in eukaryotic cells. It's been discovered in a very kind of cell varieties, it's been best studied in the segment of skeletal myocytes. It localizes at the Z-disk and has been shown to bind to α-dystrobrevin, α-actinin, and desmin to act as a mechanical linker in transmitting force laterally throughout the tissue, between the contractile myofibrils and extracellular matrix. Synemin binds to α-dystrobrevin in the dystrophin-associated protein complex to act as a mechanical "linker" between the myofibrillar network and also the semipermeable membrane. qwdvbjitgb Synemin is not essential for leading edge extension but that it may modify its properties. It is supported by our finding that synemin down-regulation decreases the motility of astrocytoma cells while not compromising in a obvious fashion leading edge extension. In addition, astrocytoma cells area unit way more migratory than prostate cancer cell lines that don't categorical synemin, synemin belongs to a pathway endowing astrocytoma cells with exceptional migratory properties. ccl11 elisa kit Synemin in astrocytoma cells by using an RNA interference (RNAi) approach. Our results demonstrate that synemin down-regulation ends up in a dramatic reduction in cell motility and impedes cell spreading. These effects on the malignant behavior are accompanied by altered dynamic properties of α-actinin and filamentlike(F) -actin, indicating that the IF protein synemin is involved in a very novel kind of cytoskeletal crosstalk. |
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8:19 AM Jul 11